Job Summary:
We are seeking a Scientist I to support biologics process development and scale-up activities within a highly collaborative laboratory environment. This position will focus on monoclonal antibody protein purification, downstream process development, chromatography, filtration, and pilot-scale bioprocess operations supporting the advancement of complex biologic therapies from development through manufacturing transfer.

Key Responsibilities:

• Scale up protein purification processes using affinity, ion exchange, hydrophobic interaction, mixed-mode chromatography, nanofiltration, depth filtration, and ultrafiltration/diafiltration.
• Perform large-scale buffer preparation to support pilot-scale purification processes.
• Operate, troubleshoot, and maintain pilot-scale bioprocess equipment including chromatography skids, filtration systems, TFF skids, mixers, tanks, pumps, and single-use assemblies.
• Perform equipment setup, column packing and qualification, buffer verification, raw material staging, and other pre-run readiness activities.
• Support process transfer into scale-up laboratories for toxicology material production and transfer to manufacturing sites for clinical material production.
• Execute and interpret experiments supporting biologics purification and downstream process development.
• Author standard operating procedures, technical reports, and scientific presentations.
• Maintain accurate and detailed experimental records using an Electronic Lab Notebook.
• Collaborate cross-functionally with scientists and technical teams to achieve project milestones and timelines.

Required Qualifications:

• Bachelor’s degree in Chemical Engineering, Chemistry, Biochemistry, or a related scientific discipline with approximately 5–7 years of relevant experience, or a Master’s degree with approximately 2–5 years of relevant experience.
• Hands-on CMC protein purification or downstream process development experience with monoclonal antibodies or similar biologic molecules.
• Strong hands-on experience with chromatography, including affinity, cation exchange, anion exchange, hydrophobic interaction, or mixed-mode separations.
• Experience with filtration operations, including depth filtration, virus filtration, sterile filtration, and tangential flow filtration.
• Experience operating bioprocess equipment such as ÄKTA systems, TFF skids, chromatography skids, mixers, tanks, pumps, or single-use systems.
• Strong understanding of biochemistry, protein purification, and bioprocess engineering principles.
• Experience independently executing and interpreting scientific experiments.
• Experience authoring standard operating procedures and technical reports and maintaining detailed laboratory documentation.
• Strong scientific writing, analytical, planning, collaboration, and verbal communication skills.

Preferred Qualifications:

• Hands-on experience with antibody or antibody-like molecule purification at pilot or GMP manufacturing scale.
• Experience scaling up downstream purification processes and transferring processes into manufacturing environments.
• Experience with cell culture harvest, affinity capture, polishing chromatography, virus filtration, and ultrafiltration/diafiltration.
• Experience with ÄKTA Ready, ÄKTA Process, ÄKTA Avant, ÄKTA Pure, Sartoflow, or comparable bioprocess equipment.
• Understanding of analytical techniques such as HPLC, ELISA, and LAL.
• Experience with high-throughput technologies or laboratory automation.
  
  Benefits:

The Company offers the following benefits for this position, subject to applicable eligibility requirements: medical insurance, dental insurance, vision insurance, 401(k) retirement plan, life insurance, long-term disability insurance, short-term disability insurance, paid parking/public transportation, paid time off, paid sick and safe time, hours of paid vacation time, weeks of paid parental leave, and paid holidays annually – as applicable.

Pay Range: $50/hr to $60/hr